Journal article
Urinary Oxygenation as a Surrogate Measure of Medullary Oxygenation during Angiotensin II Therapy in Septic Acute Kidney Injury
YR Lankadeva, J Kosaka, RG Evans, R Bellomo, CN May
Critical Care Medicine | LIPPINCOTT WILLIAMS & WILKINS | Published : 2018
Abstract
Objectives: Angiotensin II is an emerging therapy for septic acute kidney injury, but it is unknown if its vasoconstrictor action induces renal hypoxia. We therefore examined the effects of angiotensin II on intrarenal Po2 in ovine sepsis. We also assessed the validity of urinary Po2 as a surrogate measure of medullary Po2. Design: Interventional study. Setting: Research Institute. Subjects: Sixteen adult Merino ewes (n = 8/group). Interventions: Sheep were instrumented with fiber-optic probes in the renal cortex, medulla, and within a bladder catheter to measure Po2. Conscious sheep were infused with Escherichia coli for 32 hours. At 24-30 hours, angiotensin II (0.5-33.0 ng/kg/min) or salin..
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Funding Acknowledgements
Supported, in part, by grants from the National Health and Medical Research Council of Australia (1050672) and by funding from the Victorian Government Operational Infrastructure Support Grant and the Jack Brockhoff Foundation (ID 4178).Dr. Lankadeva's institution received funding from a Jack Brockhoff Foundation Early Career Medical Research Grant and was supported by Postdoctoral Fellowship from the National Heart Foundation of Australia (NHF, 100869). Dr. Evans' institution received funding from National Health and Medical Research Council of Australia. Dr. May's institution received funding from National Health and Medical Research Council of Australia, National Heart Foundation of Australia, and the Jack Brockhoff Foundation, and he received other support from a Victorian Government Operational Infrastructure Support Grant. The remaining authors have disclosed that they do not have any potential conflicts of interest.